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A third is at 3p14 rs To identify new susceptibility loci, we performed a meta-analysis of 11 GWAS, comprising 15, breast cancer cases and 18, controls together with 46, cases and 42, controls from 41 studies genotyped on a ,marker custom array iCOGS. Milne, Roger L et al. Normalized Difference Vegetation Index NDVI derived from satellite imagery was used as a proxy for residential neighborhood greenspace aggregated over various spatiotemporal scales before each assessment. Similar approaches to studying meteorology and violent crimes may further inform scientific debates on climate change and collective violence. We found evidence that many common variants of small effect contribute to genetic susceptibility to Barrett's esophagus and that SNP alleles predisposing to obesity also increase risk for Barrett's esophagus. Multiple recent genome-wide association studies GWAS have identified a single nucleotide polymorphism SNPrs, at 12p11 that is associated with breast cancer risk.

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Stepwise regression analyses were performed to identify independent association signals.

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Esophageal adenocarcinoma is a cancer with rising incidence and poor survival. Multiple recent genome-wide association studies GWAS have identified a single nucleotide polymorphism SNPrs, at 12p11 that is associated with breast cancer risk. We found evidence that many common variants of small effect contribute to genetic susceptibility to Barrett's esophagus and that SNP alleles predisposing to obesity also increase risk for Barrett's esophagus. We followed up these suggestive findings in a further smaller data set, but found no replication. People with a high genetic propensity to obesity have higher risks of esophageal metaplasia and neoplasia than people with low genetic propensity.

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